This has been bugging me a for a while, and today is the day I do something about it!
I've got a multimedia keyboard and the play button is assigned to Play/Pause in Foobar, with Global Hotkey selected. It works great except for if I have a YouTube video open but paused in my browser. When that's the case, even with FB as the active window, the Play/Pause button still actions in YouTube.
Is there a remedy for this?