Not sure if related but I've had this problem when running a portable install of foobar on an eSATA HDD. However a portable install on an external USB HDD did not have the same issues.
Are you really suggesting that foobar2000 has a bug causing your computer to act slowly with 200 KB/s disk read speed? The problem lies somewhere in your system, perhaps try replacing weird SATA drivers with Microsoft's standard AHCI drivers.
if i were you, i'll start be remove all the extra plugins, and just test foobar2000 alone. If you still have you problem, you'll be able to say it's a foobar2000 problem, otherwize, it could be a plugin! add plugins one by one by testing between each new add, you sould find in time which plugin sucks (if it's not foobar2000 core of course)HTH
How much RAM does the computer have?
How much memory does foobar2000 use when the problem occurs?
Foobar before restart: http://imageshack.us/a/img834/5107/schowek01uwo.jpgFoobar after restart: http://imageshack.us/a/img440/826/schowek01qvgdfgd.jpg
More specifically, is the computer swapping when the problem occurs?
You also said you tried with a fresh installation and you had the same problem, did the "fresh installation" included your components and DSPs? Can you try to run the same test without the mslive component?
You could generate Process Monitor log as described in Appendix C here. It might also be helpful to know what components you have installed.I have only ever had 100% disk usage with foobar2000 when decoding highly fragmented files from a slowish drive as fast as possible. Something like ReplayGain scanning entire library at once can trigger.